New Lab Analysis report for…

New Lab Analysis report for input has been added:
http://microbiomeprescription.com/Kyber/Verisana

Website for AI on KyberCompact Reports

I did a  KyberKompact analysis a while back, and just put the same same thru my new website to do analysis.

The page is at: http://microbiomeprescription.com/Kyber/Upload/

The process is simple, match the up and down errors for the items on the reports.

Kyber2

Click explore and the current recommendations appear (based on published studies) as shown below.

  • You can also take your ubiome results and match up with the selection shown above and use it that way until I get the uBiome version fully tested.
  • Clicking on include/parent will increase the recommendations to include the parent (i.e. “family”) or children (“strains”) recommendations
    • As is 142 items appeared, with parents and children the list increased to 162 items.

kyber1

There are some similar to items (i.e. red wine, resveratrol , red wine polyphenol).

The full list is shown below:

Item    Action    Avoid Weight    Take Weight

red wine
Take 1 6

fasting
Take 0 5

navy bean
Take 1 5

sesame cake/meal
Take 0 4

broad beans
Take 1 5

lupin seeds
Take 1 5

red wine polyphenol
Take 0 4

arabinoxylans
Take 0 4

daesiho-tang
Take 0 4

green tea
Take 0 4

resveratrol
Take 0 4

fish oil
Take 0 4

low processed foods diet
Take 0 4

bile
Take 0 3

esculin
Take 0 3

azithromycin
Take 0 3

meropenem
Take 0 3

helminth infection
Take 0 3

carboxymethyl cellulose
Take 0 3

cranberry bean flour
Take 0 3

cranberry polyphenols
Take 0 3

grapes
Take 0 3

heme
Take 0 3

high protein diet
Take 0 3

lingonberries
Take 0 3

melatonin
Take 0 3

metformin
Take 0 3

polysorbate 80
Take 0 3

pomegranate ellagitannins
Take 0 3

quercetin w. resveratrol
Take 0 3

rhubarb
Take 0 3

capsaicin
Take 0 3

epicor
Take 0 3

bifidobacterium longum bb536
Take 0 3

lactobacillus rhamnosus
Take 0 3

pomegranate
Take 0 3

enterococcus faecium
Take 1 3

chicory
Take 0 2

inulin
Take 0 2

jerusalem artichoke
Take 0 2

arabinoxylan
Take 0 2

rosemary
Take 0 2

cinnamon
Take 0 2

turmeric
Take 0 2

cocoa
Take 0 2

polyphenols
Take 0 2

whey
Take 0 2

mediterranean diet
Take 0 2

chemotherapy
Take 2 3

almonds/ almond skins
Take 0 1

chondrus crispus
Take 0 1

ketogenic diet
Take 0 1

magnesium
Take 0 1

whole grain and bran
Take 0 1

gum arabic
Take 0 1

lactobacillus acidophilus
Take 0 1

bifidobacterium bb-12
Take 0 1

vsl-3
Take 0 1

lactobacillus planatarum
Take 0 1

barley
Take 0 1

lactobacillus acidophilus and cellobiose
Take 0 1

raffinose
Take 0 1

oregano
Take 0 1

cacoa
Take 0 1

pea protein
Take 0 1

dates
Take 0 1

mutaflor
Take 0 1

vancomycin
Take 0 1

lactobacillus kefiri
Take 0 1

lactobacillus paracasei
Take 0 1

bifidobacteria longum
Take 0 1

bacillus licheniformis
Take 0 1

paenibacillus polymyxa (prescript assist)
Take 0 1

basil
Take 0 1

marjoram
Take 0 1

peppermint
Take 0 1

anise
Take 0 1

thyme
Take 0 1

abies alba mill.
Take 0 1

satureia montana
Take 0 1

carum carvi
Take 0 1

tannic acid
Take 0 1

propyl gallate
Take 0 1

methyl gallate
Take 0 1

lauric acid
Take 0 1

chitooligosaccharides
Take 0 1

arabinogalactan
Take 0 1

dopamine
Take 0 1

epinephrine
Take 0 1

high fiber diet
Take 0 1

low animal protein diet
Take 0 1

soy
Take 0 1

fructo-oligosaccharides
1 1

lactobacillus casei
1 1

slow digestible carbohydrates
1 1

garlic
1 1

chitosan
1 1

fat
1 1

gluten-free diet
1 1

ascophyllum nodosum
Avoid 1 0

berberine
Avoid 1 0

laminaria hyperborea
Avoid 1 0

low carbohydrate diet
Avoid 1 0

magnesium-deficient diet
Avoid 1 0

sucralose
Avoid 1 0

lacto-ovo-vegetarian diet
Avoid 1 0

high-saturated fat diet
Avoid 1 0

animal-based diet
Avoid 1 0

vegetarian
Avoid 2 1

high beef diet
Avoid 1 0

gluten-free
Avoid 1 0

iron supplements
Avoid 1 0

ß-glucan
Avoid 1 0

bifidobacterium pseudocatenulatum li09 and bifidobacterium catenulatum li10
Avoid 1 0

lactobacillus salivarius
Avoid 1 0

lactobacillus plantarum
Avoid 4 3

ß-lactam antibiotics
Avoid 1 0

refined wheat breads
Avoid 1 0

bile salts
Avoid 1 0

high animal fat diet
Avoid 1 0

high animal protein diet
Avoid 1 0

high processed foods diet
Avoid 1 0

high sugar diet
Avoid 1 0

low fiber diet
Avoid 1 0

iron sulphate
Avoid 1 0

high fat diet
Avoid 5 3

polymannuronic acid
Avoid 3 1

trametes versicolor
Avoid 3 1

lactobacillus plantarum with xylooligosaccharides
Avoid 3 1

low fodmap diet
Avoid 2 0

glycyrrhizic acid
Avoid 3 0

hyperiform
Avoid 3 0

propolis
Avoid 3 0

triphala
Avoid 3 0

chrysanthemum morifolium
Avoid 4 1

lactobacillus reuteri
Avoid 3 0

ethanol
Avoid 3 0

glyphosphate
Avoid 4 0

resistant starch
Avoid 7 3

high-protein diet
Avoid 4 0

omega 3 fatty acids
Avoid 4 0

flaxseed
Avoid 5 0

Bottom Line

The number of items above will grow as more and more studies are entered into the database.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of CFS. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

Comparing uBiomes from different dates

A reader sent me over two uBiomes taken 3 months apart and was confused by the results. Fortunately, I could upload her data and do some quick analysis (which will eventually be available as a web page).

Phylum Level Is Improving

The numbers below are the counts. It they are getting closer to normal, it is improving. If further away then a loss.

October December Normal tax_name tax_rank Change
15453 10574 45026 Actinobacteria phylum Loss
701911 424855 271874 Bacteroidetes phylum Improved
60 9124 38 Euryarchaeota phylum Loss
269622 527597 561301 Firmicutes phylum Improved
12694 22898 32511 Proteobacteria phylum Improved
271 512 4200 Synergistetes phylum Improved

We see a rare phylum (Euryarchaeota) was one of the two losses, so we really had 4 gains to 1 loss.

Class Changes

The dominant change at the class level are improvement if we take by raw counts. Both Clostridia and Bacteroidia (the two biggest classes have improved). The third largest class Erysipelotrichia has had a loss.

October December Normal tax_name tax_rank Change
15453 10574 45026 Actinobacteria class Loss
120 3024 24677 Alphaproteobacteria class Improved
15544 8799 20967 Bacilli class Loss
701911 424855 270991 Bacteroidia class Improved
527 12086 12351 Betaproteobacteria class Improved
221346 469302 511846 Clostridia class Improved
1191 6249 3903 Deltaproteobacteria class Improved
5367 1337 7271 Epsilonproteobacteria class Loss
15785 36597 10249 Erysipelotrichia class Loss
5488 199 24696 Gammaproteobacteria class Loss
60 9124 38 Methanobacteria class Loss
16946 12899 24121 Negativicutes class Loss

For this overgrowth, we have some suggestions.

class

NOTE: Walnut is reported at two places. We have contrary results from studies 😦

Order Changes

We see gain and loss here too.

October December Normal tax_name tax_rank Change
5261 2899 23920 Actinomycetales order Loss
346 249 15243 Bacillales order Loss
701911 424855 268676 Bacteroidales order Improved
527 11974 11721 Burkholderiales order Improved
5367 1337 7271 Campylobacterales order Loss
221346 468964 512463 Clostridiales order Improved
2140 7674 21896 Coriobacteriales order Improved
1191 6249 3544 Desulfovibrionales order Loss
15785 36597 10192 Erysipelotrichales order Loss
15197 8549 19016 Lactobacillales order Loss
60 9124 38 Methanobacteriales order Loss
180 199 6984 Pasteurellales order Improved
120 24 41600 Rhizobiales order Loss
16946 12899 24121 Selenomonadales order Loss
271 512 4200 Synergistales order Improved

The worst loss was for Rhizobiales, with the following suggestions coming from the website

order

It is now clear that walnuts should be avoided.

Bottom Line

One concern that I have asked is about undergrowth. Working at the genus level gets very complex here. Working at higher levels like phylum, class and order is simpler.

With this new comparison page proposed, you get better clarity of the numbers and can focus on the highest count targets.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

How to upload your uBiome for analysis [Updated]

Uploads are welcome for all conditions

Downloading your uBiome data

After logging into uBiome, you will see an ‘Advanced’ tab on your menu  bar.

  • Click it
  • A dropdown menu will appear
  • Click ‘Download’
  • Choices will appear on the left.

Some people report not seeing this. Wait 60 seconds and press F5 (Refresh) — it will usually appear then.

download

  • Click on Download Taxonomy (Json)
  • Depending on your browser, you may see the data in a new tab or be prompted for a name
  • json
  • If the above case, a Control- S should bring up a dialog to save it:
  • saveas
  • I usually add .json to the end

Using A Mac

  • MAC’s will often save it as a .webarchive which will not work for an upload. So:
    • Open a Text Editor
    • Copy  the entire page and paste it into the text editor.
    • Save the file

You are now ready to upload!

Uploading

Go to http://microbiomeprescription.com/Home/Upload

upload1

Enter your email and select the file you downloaded above. Then click ‘Upload and Consent’.

  • You may enter a second email or label to help you track the sample.

Choices After Uploading

After uploading you will see three choices (more if you have uploaded multiple samples).

  • The first one takes you to recommendations
  • The second one takes you to a screen to record or update your symptoms
  • The third one allows you to change the extra email or label on the sample.

login2
Top Choice – Recommendations

At present, the recommendations are based on OVERGROWTH only. This will be improved in the future

sample2

Visual Display in a Tree

On the menus you will see “Your microbiome tree”

menu2

This will display your data in a tree with overgrowth in red.

tree2

Your Species

Another choice on the menu is “Your species” – This is in the download from uBiome but they do not display it on their site. You can see them here. An example is below (do not expect to see this many)

species

The Second Choice is Adding symptoms

I will cover this in another post, Adding Symptoms to your uBiome.

Bottom Line

The login above, “JohnDoe@Goodle.com” with sample Id “999999” was created as a composite from uploads available when I did this post. Feel free to try it to get a feel of the site before you do an upload.

This is an education post to facilitate discussing this approach with your medical professionals. It is not medical advice for the treatment of any condition. Always consult with your medical professional before doing any  changes of diet, supplements or activity. Some items cites may interfere with prescription medicines.

Demo #1 Analysis from New Website

I have programmed (and hopefully improved) my process for analysis of uBiomes. It is still being debugged (and I doing a few of my backlog to test it).

See your Microbiome shifts in a tree

This allows a much clearer view of where hotspots of overgrowth are occurring.

tree

The factor shown are NOT from ubiome, but from my estimates (which will evolve). So what are uBiomes numbers?
save2

We are close, very close (1.74 vs 1.73, 3.71 vs 3.71,  3.96 vs 3.97).

All of the bacteria levels are hyperlinked to more information about each.

Recommendations

Recommendations are often increased and there can be some conflicts. For example, Walnuts, High Fat Diet, Vitamin D. This is because different bacteria reacts differently.

Item Action Avoid Weight Take Weight

Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10
Take 0 6.68

Cranberry bean flour
Take 0 6.06

Polymannuronic acid
Take 0 4.68

Walnuts
Take 2.93 6.47

Gallate
Take 0 3.52

Polysorbate 80
Take 2.86 5.82

Ketogenic diet
Take 0 2.86

Low fat diets
Take 0 2.86

L-Taurine
Take 0 2.86

Quercetin w. Resveratrol
Take 0 2.84

Bacillus subtilis
Take 0 2.71

Plant-rich diet
Take 0 2.71

Tannin
Take 0 2.71

Flaxseed
Take 0 2.12

High sugar diet
Take 0 2.09

Partial Sleep Deprivation
Take 0 1.2

Tannic acid
Take 0 1.2

Chamomile
Take 0 0.72

Chicory
Take 0 0.72

Grapes
Take 0 0.72

Inulin
Take 0 0.72

high-saturated fat diet
Take 0 0.72

Barley
Avoid 0.72 0

Bile
Avoid 0.72 0

High animal protein diet
Avoid 0.72 0

High protein diet
Avoid 0.72 0

Milk-derived saturated fat
Avoid 0.72 0

Pyruvate
Avoid 0.72 0

Daesiho-tang
Avoid 1.2 0

Ganoderma lucidum mycelium
Avoid 1.2 0

Gynostemma pentaphyllum
Avoid 1.2 0

Schisandra chinensis
Avoid 1.2 0

Vitamin D
Avoid 4.02 2.71

Saccharin
Avoid 2.09 0

Saccharomyces boulardii
Avoid 2.12 0

Sunflower Oil
Avoid 2.54 0

High fruit intake
Avoid 2.71 0

Carboxymethyl cellulose
Avoid 2.86 0

Navy bean
Avoid 2.86 0

Berberine
Avoid 2.95 0

Proton-pump inhibitors
Avoid 2.96 0

Resistant starch
Avoid 2.96 0

High meat diet
Avoid 3.43 0

High fat diet
Avoid 5.57 2.09

Acetic acid
Avoid 5.82 0

Isobutyric acid
Avoid 5.82 0

Isovaleric acid
Avoid 5.82 0

oligosaccharide
Avoid 6.06 0

Learning More

Clicking on an item like Vitamin D, will show you what we know that vitamin D changes (with the source of information)

gut

Bottom Line

The new do-the-analysis yourself site does a deeper evaluations of each item and their impact with full transparency to the data source.

I hope to have public uploads enabled within the week. There is a lot of data to be added to it, so it may be a month or more before that is complete. DataPunk data is complete — so there is a reasonable amount of data now (i.e. for the above, we have a long list of items suggested already).

If there are too many items, just go for the ones with the highest weights.