lassesen 2:44 am on October 10, 2017  

Reducing Subdoligranulum genus

For updated information see Microbiome Prescription

Another high bacteria genus — this appears to occur in only 1/4 of the CFS uBiomes that I have seen.

For updated information see Microbiome Prescription

DataPunk.Net Data

NUTRIENTS/ SUBSTRATES

INHIBITED BY

ENHANCED BY

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PubMed Data

There are some 28+ articles on PubMed.

  • Disease:
    • “At the genus level, we observed significant increases in the numbers of Sphingomonas, Sutterella, Bifidobacterium, Collinsella, Clostridium sensu stricto, Clostridium IV, Enterococcus, Lactobacillus, Roseburia, Faecalibacterium, Ruminococcus, Subdoligranulum, and Akkermansia in the Food Sensitive group. ” [2016]
    • “Behçet’s syndrome patients were significantly depleted in the genera Roseburia and Subdoligranulum.” [2015]
  • Diet:
    • “a low fermentable substrate diet ..increased abundance of bacterial taxa belonging to the genera Sporobacter (P<0.05) and Subdoligranulum” [2014]
    • higher (Subdoligranulum) among vegetarians, indicating the association of dietary type with bacterial community composition. [2014]
    • “Omega3 ..remarkable increase in ..and Subdoligranulum (4.93% versus 7.57%). ” [2016]
  • Prebiotics:
    • ” short-chain fructo-oligosaccharides (scFOS) on the gut bacterial populations…Subdoligranulum variabile-like species were elevated” [2010]
    • “The inhibitory effect of xylooligosaccharide (XOS) on other opportunistic pathogens, such as Clostridia, Streptococcaceae, and Subdoligranulum, further supports that XOS can potentially promote an optimal gut microbiota profile” [2015]
    • ” A negative correlation was detected between inulin utilization and Subdoligranulum (r = −0.73, p ≤ 0.01) [2013]
  • Probiotics:
    • ” Lactobacillus salivarius SMXD51…subdoligranulum sp. increase.” [2017]
    • Subdoligranulum was higher in mice supplemented with L. casei (p < 0.05), whereas it tended to be higher in mice supplemented with B. breve (p = 0.05), as compared with control mice” [2016]
  • Antibiotics:
    • “Vancomycin targets …as for the low levels of Subdoligranulum.” [2015]

Bottom Line

Avoid

  • Lactobacillus salivarius
  • Lactobacillus Casei
  • Bifidobacterim Breve
  • Omega 3
  • Walnuts (and likely no  pomegranate – both are high urolithin)
  • Saccharomyces boulardii
  • Berberine

Take

  • Inulin

While there is no direct evidence, I would suggest trying some of the probiotics for Anaerostipes.